Skin Cancer Cells Sabotage Brain’s Immune Defenses With Alzheimer’s Protein
Amyloid beta, a protein regarded to construct-up in the brains of DOI: 10.1158/2159-8290.CD-21-1006
Along with Hernando and Kleffman, study authors in the Department of Pathology at NYU Grossman School of Medicine were Grace Levinson, Sorin Shadaloey, Francisco Galan-Echevarria, Alcida Karz, Diana Argibay, Richard Von-Itter, Alfredo Floristan, Gillian Baptiste, Nicole Eskow, Robert Rogers, and George Jour. Also NYU Langone Health authors were Indigo Rose and Shane Liddelow of the Neuroscience Institute, Lili Blumenberg and Kelly Ruggles in the Department of Medicine, Avantika Dhabaria and Beatrix Ueberheide in the Department of Biochemistry and Molecular Pharmacology; James Tranos, Jenny Chen, and Youssef Zaim Wadghiri in the Department of Radiology; Eleazar Vega Saenz de Miera, Melissa Call, and Iman Osman in the Department of Dermatology; Paul Mathews in the Department of Psychiatry, and Robert Schneider in the Department of Microbiology. Also authors were Eitan Wong and Yueming Li in the Chemical Biology Program at Memorial Sloan Kettering Cancer Center, and Ronald DeMattos of the Department of Neurobiologics at Eli Lilly.
The study was supported by National Institutes of Health grants (NIH) NCI 5R01CA243446, P01CA206980, NCI P50 CA225450, F30CA221068, 5 T32 CA009161-37, P30CA016087, NIGMS 5 T32 GM007308-41, and S10 Grants NIH/ORIP S10OD01058 and S10OD018338. Also supporting the work were an American Cancer Society-Melanoma Research Alliance Team Science Award, a Vilcek Foundation Scholarship, a Fundacion Ramon Areces fellowship, the Cure Alzheimer’s Fund, the Blas Frangione Foundation, the MD Anderson Neurodegenerative Consortium, Anonymous Donors, and NYU Grossman School of Medicine.
Of note, none of the study authors from NYU Grossman School of Medicine received any financial compensation from Eli Lilly, which supplied the beta secretase inhibitor used in the study. Study author Ronald DeMattos is a full-time employee at Eli Lilly. Eva Hernando, Robert Schneider and Kevin Kleffman are inventors on pending International Patent Application No. PCT/US2019/033377 filed on May 21, 2019, for a method-of-treatment patent in the use of an anti-amyloid beta therapeutic. Shane Liddelow is a founder of AstronauTx Ltd, a company making therapies to target astrocytes in neurodegenerative disease. These relationships are being managed in accordance with the policies of NYU Langone Health.
